Growth differentiation factor

Growth differentiation factors (GDFs) are a subfamily of proteins belonging to the transforming growth factor beta superfamily that have functions predominantly in development.^[1]

Types

Several members of this subfamily have been described, and named GDF1 through GDF15.

GDF1 is expressed chiefly in the nervous system and functions in left-right patterning and mesoderm induction during embryonic development.^[2]
GDF2 (also known as BMP9) induces and maintains the response embryonic basal forebrain cholinergic neurons (BFCN) have to a neurotransmitter called acetylcholine, and regulates iron metabolism by increasing levels of a protein called hepcidin.^[3]^[4]
GDF3 is also known as "Vg-related gene 2" (Vgr-2). Expression of GDF3 occurs in ossifying bone during embryonic development and in the thymus, spleen, bone marrow brain, and adipose tissue of adults. It has a dual nature of function; it both inhibits and induces early stages of development in embryos.^[5]^[6]^[7]
GDF5 is expressed in the developing central nervous system, with roles in the development of joints and the skeleton, and increasing the survival of neurones that respond to a neurotransmitter called dopamine.^[8]^[9]^[10]
GDF6 interacts with bone morphogenetic proteins to regulate ectoderm patterning, and controls eye development.^[11]^[12]^[13]
GDF8 is now officially known as myostatin and controls the growth of muscle tissue.^[14]
GDF9, like GDF3, lacks one cysteine relative to other members of the TGF-β superfamily. Its gene expression is limited to the ovaries, and it has a role in ovulation.^[15]^[16]
GDF10 is closely related to BMP3 and has a roles in head formation and, it is presumed, in skeletal morphogenesis.^[17]^[18] It is also known as BMP-3b.
GDF11 controls anterior-posterior patterning by regulating the expression of Hox genes,^[19] and regulates the number of olfactory receptor neurons occurring in the olfactory epithelium,^[20] and numbers of retinal ganglionic cells developing in the retina.^[21]
GDF15 (also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB) has a role in regulating inflammatory and apoptotic pathways during tissue injury and certain disease processes.^[22]^[23]^[24]

References

^ Herpin A, Lelong C, Favrel P (2004). "Transforming growth factor-beta-related proteins: an ancestral and widespread superfamily of cytokines in metazoans". Dev Comp Immunol 28 (5): 461–85. doi:10.1016/j.dci.2003.09.007. PMID 15062644.
^ Rankin C, Bunton T, Lawler A, Lee S (2000). "Regulation of left-right patterning in mice by growth/differentiation factor-1". Nat Genet 24 (3): 262–5. doi:10.1038/73472. PMID 10700179.
^ Lopez-Coviella I, Follettie M, Mellott T, Kovacheva V, Slack B, Diesl V, Berse B, Thies R, Blusztajn J (2005). "Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons". Proc Natl Acad Sci USA 102 (19): 6984–9. doi:10.1073/pnas.0502097102. PMC 1088172. PMID 15870197. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1088172.
^ Truksa J, Peng H, Lee P, Beutler E (2006). "Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6". Proc Natl Acad Sci USA 103 (27): 10289–93. doi:10.1073/pnas.0603124103. PMC 1502450. PMID 16801541. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1502450.
^ Levine A, Brivanlou A (2006). "GDF3 at the crossroads of TGF-beta signaling". Cell Cycle 5 (10): 1069–73. doi:10.4161/cc.5.10.2771. PMID 16721050.
^ Levine A, Brivanlou A (2006). "GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos". Development 133 (2): 209–16. doi:10.1242/dev.02192. PMID 16339188.
^ Chen C, Ware S, Sato A, Houston-Hawkins D, Habas R, Matzuk M, Shen M, Brown C (2006). "The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo". Development 133 (2): 319–29. doi:10.1242/dev.02210. PMID 16368929.
^ O'Keeffe G, Dockery P, Sullivan A (2004). "Effects of growth/differentiation factor 5 on the survival and morphology of embryonic rat midbrain dopaminergic neurones in vitro". J Neurocytol 33 (5): 479–88. doi:10.1007/s11068-004-0511-y. PMID 15906156.
^ Buxton P, Edwards C, Archer C, Francis-West P (2001). "Growth/differentiation factor-5 (GDF-5) and skeletal development". J Bone Joint Surg Am 83-A Suppl 1 (Pt 1): S23–30. PMID 11263662.
^ Francis-West P, Parish J, Lee K, Archer C (1999). "BMP/GDF-signalling interactions during synovial joint development". Cell Tissue Res 296 (1): 111–9. doi:10.1007/s004410051272. PMID 10199971.
^ Chang C, Hemmati-Brivanlou A (1999). "Xenopus GDF6, a new antagonist of noggin and a partner of BMPs". Development 126 (15): 3347–57. PMID 10393114.
^ Asai-Coakwell M, French C, Berry K, Ye M, Koss R, Somerville M, Mueller R, van Heyningen V, Waskiewicz A, Lehmann O (2007). "GDF6, a novel locus for a spectrum of ocular developmental anomalies". Am J Hum Genet 80 (2): 306–15. doi:10.1086/511280. PMC 1785352. PMID 17236135. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1785352.
^ Hanel M, Hensey C (2006). "Eye and neural defects associated with loss of GDF6". BMC Dev Biol 6: 43. doi:10.1186/1471-213X-6-43. PMC 1609107. PMID 17010201. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1609107.
^ McPherron AC, Lawler AM, Lee SJ (May 1997). "Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member". Nature 387 (6628): 83–90. doi:10.1038/387083a0. PMID 9139826.
^ Juengel J, Bodensteiner K, Heath D, Hudson N, Moeller C, Smith P, Galloway S, Davis G, Sawyer H, McNatty K (2004). "Physiology of GDF9 and BMP15 signalling molecules". Anim Reprod Sci 82-83: 447–60. doi:10.1016/j.anireprosci.2004.04.021. PMID 15271472.
^ Hreinsson J, Scott J, Rasmussen C, Swahn M, Hsueh A, Hovatta O (2002). "Growth differentiation factor-9 promotes the growth, development, and survival of human ovarian follicles in organ culture". J Clin Endocrinol Metab 87 (1): 316–21. doi:10.1210/jc.87.1.316. PMID 11788667.
^ Hino J, Kangawa K, Matsuo H, Nohno T, Nishimatsu S (2004). "Bone morphogenetic protein-3 family members and their biological functions". Front Biosci 9: 1520–9. doi:10.2741/1355. PMID 14977563.
^ Cunningham N, Jenkins N, Gilbert D, Copeland N, Reddi A, Lee S (1995). "Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3". Growth Factors 12 (2): 99–109. doi:10.3109/08977199509028956. PMID 8679252.
^ Andersson O, Reissmann E, Ibáñez C (2006). "Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis". EMBO Rep 7 (8): 831–7. doi:10.1038/sj.embor.7400752. PMC 1525155. PMID 16845371. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1525155.
^ Wu H, Ivkovic S, Murray R, Jaramillo S, Lyons K, Johnson J, Calof A (2003). "Autoregulation of neurogenesis by GDF11". Neuron 37 (2): 197–207. doi:10.1016/S0896-6273(02)01172-8. PMID 12546816.
^ Kim J, Wu H, Lander A, Lyons K, Matzuk M, Calof A (2005). "GDF11 controls the timing of progenitor cell competence in developing retina". Science 308 (5730): 1927–30. doi:10.1126/science.1110175. PMID 15976303.
^ Zimmers T, Jin X, Hsiao E, McGrath S, Esquela A, Koniaris L (2005). "Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury". Shock 23 (6): 543–8. PMID 15897808.
^ Hsiao E, Koniaris L, Zimmers-Koniaris T, Sebald S, Huynh T, Lee S (2000). "Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury". Mol Cell Biol 20 (10): 3742–51. doi:10.1128/MCB.20.10.3742-3751.2000. PMC 85678. PMID 10779363. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85678.
^ Ago T, Sadoshima J (2006). "GDF15, a cardioprotective TGF-beta superfamily protein". Circ Res 98 (3): 294–7. doi:10.1161/01.RES.0000207919.83894.9d. PMID 16484622.

External links

BMPedia - the Bone Morphogenetic Protein Wiki

Cell signaling: TGF beta signaling pathway

TGF beta superfamily of ligands	TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin and inhibin, Anti-müllerian hormone, Nodal)

TGF beta receptors (Activin, BMP)	TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) · ACVRL1 · BMPR1 (BMPR1A · BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) · AMHR2 · BMPR2 TGFBR3: betaglycan

Transducers/SMAD	R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) · I-SMAD (SMAD6, SMAD7) · SMAD4

Ligand inhibitors	Cerberus · Chordin · DAN · Decorin · Follistatin · Gremlin · Lefty · LTBP1 · Noggin · THBS1

Coreceptors	BAMBI · Cripto

Other	SARA

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)